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Liquid Separation

The liquid separations laboratory specializes in the characterization of semi- and non-volatile compounds. Impact Analytical has a state-of-the-art liquid separations laboratory that includes liquid chromatography-mass spectrometry (LC-MS), high performance liquid chromatography (HPLC), ultra-high performance liquid chromatography (UPLC) and size exclusion chromatography (SEC). These systems can analyze samples ranging from pharmaceutical APIs to polymers to proteins.

Samples of past projects in this laboratory include:

• Unknown component characterization

• Molecular weight, distribution and polydispersity determination

• Pharmaceutical API characterization

• GLP or cGMP characterization

• Polymer additives analysis/quantitation Residual monomer and oligomer detection

• Surfactant analysis

• Impurities

• Proteins and amino acid characterization

Detection systems available to the liquid separations laboratory include: 

• Ultraviolet-visible (UV-Vis) spectroscopy

• Evaporative light scattering detectors (ELSD)

• Mass spectrometry (MS)

• Charged aerosol detection (CAD)

• Multi-angle laser light scattering (MALLS)

• Refractive index (RI)